Điện di ion bằng dòng điện một chiều trong xử trí thoát mạch ion canxi: báo cáo ca lâm sàng và tổng quan tường thuật

Abstract

ABSTRACT

Objectives: To evaluate the preliminary clinical efficacy of direct current iontophoresis in the treatment of calcium extravasation, and to analyze the potential mechanism of action of this method through a literature review. Methods: We report two clinical cases of Calcium chloride (CaCl₂) extravasation treated with iontophoresis aimed at facilitating the migration of calcium ions out of the injured tissue, combined with a review of the literature on pathophysiology and current management strategies. Results: In the early intervention case (4 hours post-incident), the lesion healed completely after 10 treatment sessions without sequelae. In the late presentation case (40 hours post-incident), this method helped to localize the injury and significantly reduce the necrotic area compared to the initial prognosis. The literature review indicates that iontophoresis has a theoretical basis for facilitating ion transport under the influence of an electric field, thereby potentially assisting in reducing calcium ion concentration in the interstitial tissue. Conclusion: Direct current iontophoresis is a non-invasive, low-cost method with potential as a supportive treatment for calcium extravasation, especially when applied early. Further large-scale controlled studies are needed to establish the efficacy and mechanism of action of this method.