BIẾN ĐỔI TRÊN GEN COX-2 TY THỂ Ở BỆNH NHÂN UNG THƯ ĐẠI TRỰC TRÀNG

Abstract

Carried ouf fo sCre 3 : tumor tissues, 13 blood samples ts fe ates TP SE COX-2 gene a 2 samples of blood doner used as controls. 13 alterations of eee cancer (CRC) ss + using DNA sequencing and PCR-RFLP methods in whi -2 gene were detec si substitution of amino acid. Percentage of sampl which five alterations resu group, CRC blood group and blood ‘control ples carrying G7853A in CRC tissues respectively. The G7853A alteration was meee ở was 20,4%, 23,1% and 49,3% | study demonstrated a lack of association 4 to be a somatic mutation. overall, the susceptibility. However, a tendency to increa etween G7853A alteration and CRG ' the G7853A alteration (OR: 1,25; 95% CỊ: sẻ ne of CRC was in patients 1 arbouring associated wali tumor size and T stage (P<o Xi lì This alteration. was significant \ characteristics including the age, gender. so ), but not with some other path ojogica! stage (P>0,08). _ , tumor location, ceil differentiation and TNM