MỘT SỐ YẾU TỐ TẾ BÀO TRONG TIÊN LƯỢNG Ở BỆNH NHÂN ĐA U TỦY XƯƠNG CÓ SUY THẬN ĐƯỢC ĐIỀU TRỊ TẠI BỆNH VIỆN BẠCH MAI

Abstract

Objective: 1. To describe some immune system cells factors in multiple myeloma patients with renal failure. 2. Analysis of the correlation between immune system cells factors and treatmeant outcome in patients of study. Subjects and methods Study design: Retrospective cohort sudy. 51 multiple myeloma with renal failure at the Hematology and Blood Transfusion Center of Bach Mai Hospital from 2019 to 2022 were analyzed before treatment about: the NLR (neutrophil lymphocyte ratio), LMR (lymphocyte monocyte ratio), NMLR (neutrophil +monocyte/ lymphocyte ratio), PLR (platelet lymphocyte ratio), HGB (hemoglobin concentration), PLC (platelet count) and assessed their responses and OS (overall survival).Results: The median age of the patients was 58,5 years old. The males of patient group were 64,7%, the most common type disease was light chain multiple myeloma (49.1%), the NLR ≥2, LMR <3,6, HGB <100 g/l, PLC <150 G/l, were poor prognostic factors associated with reduced overall survival (OS), and rate very good partial remission (VGPR) or better. Conclusion: High NLR, NMLR and low LMR,HGB and PLC was found to be poor prognosis factors to OS and responses in multiple myeloma patients with renal failure