MỨC ĐỘ MẤT ĐOẠN LỚN VÀ SỐ BẢN SAO DNA TY THỂ TRONG MÔ PHỔI CỦA BỆNH NHÂN MẮC BỆNH PHỔI KHÔNG UNG THƯ

Abstract

Objectives: The study was conducted to investigate mtDNA copy number and level of large deletion in the lung tissue of patients with non-cancerous lung disease in order to supply mtDNA data for potential application in the diagnosis and treatment of lung diseases in Vietnam. Subjects and methods: The mtDNA copy number and level of large deletion were determined in 51 lung tissue samples of patients with non-cancerous lung disease by realtime PCR. Statistical comparison of mtDNA copy number and level of large deletion was performed between two groups of patients with non-cancerous lung disease and non-small cell lung cancer. Results: The mtDNA copy number and level of large-scale deletion in the group of patients with non-cancerous lung disease was lower than that in the group of patients with non-small cell lung cancer (P < 0.05). In addition, the age was negatively correlated with the level of mtDNA large-scale deletion in the lung tissue of patients with noncancerous lung disease (r = -0.3621; p = 0.0090). Conclusions: The mtDNA copy number and level of large-scale deletion could be a potential biomarkers for evaluating, monitoring disease progression of patients with noncancerous lung disease in the group of patients with lung disease.