ĐÁNH GIÁ MỘT SỐ DẤU ẤN SINH HỌC Ở QUÂN NHÂN TRẦM CẢM NGƯỜI VIỆT NAM

Abstract

Depression is a neurological disease that arises due to disturbances in the biological activity of the brain or due to psychological stress, leading to abnormalities in behavior. The diversity of patients and the number of people with depression are increasing at an alarming rate in every country in the world. In Vietnam, the military is a special profession with a large force of soldiers, so the number of cases also tends to increase. This study was conducted to quantify and compare several biomarkers in a group of depressed military personnel and evaluate the association of biomarkers with depression severity. Blood and serum samples from normal or depressed soldiers (n=58) were collected at Military Hospital 175. Patients were diagnosed through HAMD testing (Hamilton –D). Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) were quantified using the Human BDNF ELISA, Human NT-3 ELISA, and Human NT-4 ELISA kit. Changes in biochemical indicators such as cholesterol, triglycerides, and glucose; The hormones FT3, FT4, and TSH were also analyzed. The obtained results showed that BDNF, NT-3, and NT-4 levels in the serum of depressed soldiers decreased significantly compared to normal (p < 0.05). Compared with serum samples from normal soldiers, samples from depressed soldiers had biochemical indices such as cholesterol, triglyceride, glucose, and FT3 tend to be higher.