THE MITOCHONDRIAL DNA COPY NUMBER AND LEVEL OF LARGE-SCALE DELETIONS IN LUNG TISSUE OF PATIENTS WITH NON-CANCEROUS LUNG DISEASE
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Abstract
Objectives: The study was conducted to investigate mtDNA copy number and level of large deletion in the lung tissue of patients with non-cancerous lung disease in order to supply mtDNA data for potential application in the diagnosis and treatment of lung diseases in Vietnam. Subjects and methods: The mtDNA copy number and level of large deletion were determined in 51 lung tissue samples of patients with non-cancerous lung disease by realtime PCR. Statistical comparison of mtDNA copy number and level of large deletion was performed between two groups of patients with non-cancerous lung disease and non-small cell lung cancer. Results: The mtDNA copy number and level of large-scale deletion in the group of patients with non-cancerous lung disease was lower than that in the group of patients with non-small cell lung cancer (P < 0.05). In addition, the age was negatively correlated with the level of mtDNA large-scale deletion in the lung tissue of patients with noncancerous lung disease (r = -0.3621; p = 0.0090). Conclusions: The mtDNA copy number and level of large-scale deletion could be a potential biomarkers for evaluating, monitoring disease progression of patients with noncancerous lung disease in the group of patients with lung disease.
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Keywords
non-cancerous lung disease, mtDNA, large-scale deletions level, mtDNA copy number
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