NGHIÊN CỨU ĐẶC ĐIỂM TUỔI, GIỚI, HÒA HỢP HLA VÀ MỐI LIÊN QUAN VỚI ĐÁI THÁO ĐƯỜNG Ở BỆNH NHÂN SAU GHÉP THẬN

Abstract

Objectives: Investigate the characteristics of age, gender, human leukocyte antigen (HLA) matching, and relationship with the new-onset diabetes mellitus after renal transplantation. Subjects and methods: We recruited 508 patients more than three months after the kidney transplant at Viet Duc University Hospital from September 2017 to April 2018 in the study. All patients volunteered to participate in the research and collecting the information on age, gender, and (HLA) matching of study subjects through pre-transplant selection records. Patients diagnosed with diabetes according to the American Diabetes Association. Results: Average age of patients was 42.41 ± 11.18; male accounted for 68.11%, female for 31.89%; HLA matching with 2 and 3 alleles were 26.91% and 23.23%, respectively; the age group 50-59 onset diabetes were the highest proportion as 41.03%, with p <0.01; The prevalence of diabetes in male is 17.3%, higher than that of female 10.49% with the difference having a statistically significant difference p =0,038. Conclusion: The results show that age and gender factors are related to the development of diabetes after kidney transplantation, which is the basis for personalizing high-risk subjects to develop treatment strategies and preventive the new-onset diabetes mellitus after renal transplantation.