ĐÁNH GIÁ TÁC DỤNG BẢO VỆ CỦA LIQUIRITIN ĐỐI VỚI TẾ BÀO HEK293 TRONG TỔN THƯƠNG THIẾU ÔXI-TÁI CUNG CẤP ÔXI GÂY BỞI COBALT CHLORIDE

Abstract

Liquiritin (Liquiritigenin-4'-O-glucoside, Liq) is a flavanone glycoside compound primarily found in the roots of licorice plants of the genus Glycyrrhiza. Although it has been used in many pathological studies, the effect of Liq on HEK293 cells in Cobalt Chloride (CoCl₂)-induced injury has not been elucidated. Objectives: This study aimed to evaluate the effect of Liq on the viability of HEK293 cells under normal culture conditions and under hypoxia/reoxigenation (HR) conditions induced by CoCl₂. Methods: HEK293 cells were grown in normal conditions and in HR conditions supplemented with Liq at the concentration range of 10÷160 µM. Cell viability in experimental groups was analyzed by CCK-8. Results: Research results show that 100÷400 µM CoCl₂ reduces the viability of HEK293 cells. The addition of Liq 40÷160 µM significantly increased the survival rate of these cells (p<0.05). Conclusion: The obtained results are preliminary data on the effect of Liq in protecting HEK293 cells against CoCl2-induced injury.