Effects of GYDENPHY caspules on streptozotocin-induced type 1 diabetic in Swiss mouse model
Main Article Content
Abstract
Objective: Evaluation the hypoglycemic effect of Gydenphy capsules on Streptozotocin-induced type 1 diabetic in Swiss mouse model.
Methods: The type 1 diabetic model was established by intraperitoneal injections of Streptozocin 150mg/kg in Swiss mouse. Then, the Gydenphy were orally administered daily at a dose of 576 mg/kg/day or 1152 mg/kg/day in 10 days. Blood glucose concentration in the Gydenphy oral groups with that of water control group and the intraperitoneal insulin injection group was compared.
Results: Blood glucose concentration in the groups using Gydenphy (dose576 mg/kg/24h and dose 1152 mg/kg/24h) significal decreased compared to the distilled water group at (p <0.05 at the time of 4 hours, 8 hours; p <0.01 at the time of 3, 10 days). The hypoglycemic effect of Gydenphy at 576mg/kg/day and 1152 mg/kg/day at 4 hours, 8 hours and 3 days were inferior to insulin 0.1 UI/kg/day for glycemic control. However, the hypoglycemic effect ofGydenphy were equivalent to insulin after 10 consecutive days on treatment.
Conclusion: Gydenphy capsules have hypoglycemic effects onStreptozotocin-induced type 1 diabetes in Swiss mouse model.
Article Details
Keywords
Type 1 diabetes, Gydenphy, Swiss mice
References
Most read articles by the same author(s)
- Thị Thanh Nhạn Lê, Đức Thiện Nguyễn , Ngọc Thảo Phạm , Hoàng Ngân Nguyễn , ĐÁNH GIÁ TÁC DỤNG CHỐNG PHÌ ĐẠI VÀ CHỐNG OXY HÓA CỦA VIÊN NANG TIỀN LIỆT HV TRÊN ĐỘNG VẬT THỰC NGHIỆM , Vietnam Journal of Physiology: Vol. 25 No. 4 (2021)
- Bui Thi Thu Ha, Vu Manh Hung, Nguyen Thanh Hai, Nguyen Thanh Ha Tuan, Effects of NP on some hematological and immunological indices in sarcoma TG180-bearing mice , Vietnam Journal of Physiology: Vol. 25 No. 2 (2021)