KHẢO SÁT MỐI LIÊN QUAN GIỮA ĐA HÌNH GEN ANRIL VỚI HỘI CHỨNG ĐỘNG MẠCH VÀNH MẠN VÀ CÁC YẾU TỐ NGUY CƠ TIM MẠCH TẠI CẦN THƠ

Abstract

      Objectives: To compare the distribution and determine the independent associations of the rs1333040, rs1333049, and rs2383207 polymorphisms gene ANRIL in patients with chronic coronary syndrome (CCS). Materials and methods: This case-control study included 213 individuals who underwent coronary angiography at five hospitals in Can Tho City, Vietnam, during 2025-2026, comprising 106 patients with ≥50% coronary artery stenosis (case group) and 107 individuals with <30% stenosis (control group). Genotypes were determined by Sanger sequencing. Three multivariable logistic regression models, each including one polymorphism, were constructed with CCS as the dependent variable. Results: The mean age was 65.84 ± 9.70 years in the case group and 61.92 ± 10.20 years in the control group. Physical inactivity (70.8% vs 43.9%; p < 0.001) and a family history of cardiovascular disease (21.7% vs 10.3%; p = 0.023) were more prevalent in the case group. The genotype frequencies were 46.2%, 47.6%, and 6.1% for TT, CT, and CC of rs1333040; 12.7%, 47.6%, and 39.6% for GG, GC, and CC of rs1333049; and 46.5%, 45.1%, and 8.5% for GG, GA, and AA of rs2383207, respectively. All three polymorphisms were in Hardy-Weinberg equilibrium and showed no significant differences between the two groups (p > 0.05). None of the genotypes were independently associated with CCS in the three multivariable models. Physical inactivity was independently associated with CCS in all three models, with ORs of 3.31 (95% CI: 2.13-5.15; p < 0.001), 3.27 (95% CI: 2.10-5.10; p < 0.001), and 3.36 (95% CI: 2.16-5.23; p < 0.001), respectively. A family history of cardiovascular disease also reached statistical significance in all three adjusted models (p < 0.05). Conclusions: This study characterized the genotype and allele frequencies of the ANRIL rs1333040, rs1333049, and rs2383207 polymorphisms among patients with CCS and healthy Vietnamese individuals. No independent association was identified between any of the three polymorphisms and CCS. After multivariable adjustment, physical inactivity and a family history of cardiovascular disease remained independently associated with CCS.