Sự thay đổi một số chỉ số tiêu sợi huyết trong xét nghiệm NaTEM ở bệnh nhân có tình trạng nhiễm khuẩn

Abstract

Fibrinolysis inhibition has been detected in the early stage of sepsis with non-activated thromboelastometry (NaTEM). Objective: Comparison of the value between some fibrinolysis parameters in NaTEM and other parameters such as procalcitonin, CRP and neutrophil count in the early diagnosis of sepsis. Methods: 98 patients were included, of whom 65 had sepsis and 33 did not. Blood samples were obtained within 24 hours from admission and simultaneously sent to labs for NaTEM, procalcitonin, CRP and white blood cell count. Results: There were significant differences in LI30, LI45, LI60, ML and procalcitonin between sepsis and non-sepsis patients (p<0.05). The diagnostic accuracy with the area under the curve (AUC) of ML, LI60 and LI45 were 0.862 (CI: 0.777-0.946, p<0.05); 0.832 (CI: 0.738-0.926, p<0.05); and 0.809 (CI: 0.696-0.922, p<0.05), respectively. There were no significant differences in CRP and neutrophil count between the 2 groups. Conclusions: Hypofibrinolysis appears very early in sepsis, and its detection could be used as an effective measurement to differentiate sepsis from non-sepsis, better than other biomarkers such as CRP and neutrophil count. Thus, LI60 and the ML lysis index in NaTEM could play an important role in the early diagnosis of sepsis in the near future.