Sàng lọc nguy cơ sinh con mắc bệnh tan máu bẩm sinh tại huyện Định Hóa, tỉnh Thái Nguyên

Abstract

Thalassemia is the most common inherited blood disorder in Vietnam, but the screening program for the carrier to prevent new cases with thalassemia severe in the community is lacking. This study aims to evaluate the results of the screening criteria for thalassemia carriers in Community Health Center. Cross-sectional study was applied. Pregnant women under 12 weeks were enrolled in the study. OF-Osmotic fragility 0.36% was used to screening for thalassemia carrier. The phenotype was diagnosed by electrophoresis in the next step; Prenatal diagnosis will be conducted for the couple who was positive in HbTyping. After 12 months of screening, 226 participants are volunteers in the study. 12 couples were positive with the screening test. 2 couples were diagnosed with B thalassemia heterozygotes. A fetus was done with prenatal diagnosis. After the counseling, 226 participants accepted to screen for thalassemia, 12 pairs agreed to do the diagnostic of phenotype, one couple decided to do prenatal diagnosis