Nghiên cứu giá trị chẩn đoán của Beta2-Microglobulin và mối liên quan với một số chỉ số hóa sinh máu trên bệnh nhân đa u tủy xương và u lympho ác tính

Abstract

Objective: To investigate the diagnostic value of beta2-microglobulin (B2M) in multiple myeloma (MM) and malignant lymphomas (ML) and to analyse the correlation between the concentration of B2M with some biochemical parameters in MM and ML. Subjects and methods: Blood levels of B2M were measured in 42 patients with MM, 43 with ML and 56 non — diseased people (NDP). Results: The concentration of B2M in MM, ML and NDP group was 4.7 + 5.4 mg/L, 3.6 + 3.7 mg/L and 1.8 + 0.3 mg/L, respectively. The concentration of B2M is valuable in diagnosis of MM with sensitivity at 61.9%, specificity at 98.2%, positive predictive value (PPV) at 61.9% and negative predictive value (NPV) at 100% and cut-off value of 2.36 mg/L and it value is lower than in ML group. The concentration of B2M in MM has the very high positive correlation with serum levels of ure, creatinin (r = 0,89; r = 0,81) and p < 0,05 and in ML group it correlated only with albumin concentration. Conclusions: B2M is a useful marker in diagnosis of MM while this marker has lower value in ML. In MM, the relationship between the concentration of B2M with serum levels of ure, creatinin in contrast in MM, only the relationship between B2M and albumin with very low level