PHƠI NHIỄM TRƯỚC SINH VỚI AXIT VALPROIC GÂY THAY ĐỔI HÀNH VI Ở CHUỘT CỐNG

Abstract

This study was conducted in order to model experimentally the autism
in laboratory rats by intraperitoneal injection of valproic acid (VPA) dosed 500 and 600
mg/kg at 12.5 gestational day and assessed behavioral changes in pubs. The results showed
1) deficit in pub's ultrasound vocalization and 2) prenatal exposure to VPA impaired
attention-switching ability. Though exposure to VPA during gestation seemed unaffected
learning and memory abilities, but deteriorated their flexibility. Thus, prenatal exposure
VPA dosed 500 and 600 mg/kg compromised communicative and cognitive functions in
rat's pubs. Therefore, these doses could be used to replicate autism-like behavioral trait
experimentally in rats.