CURCUMINOIDS ỨC CHẾ SỰ PHÁT TRIỂN CỦA TẾ BÀO UNG THƯ TỦY KMS-20 BẰNG CÁCH LÀM THAY ĐỔI CHỨC NĂNG TY THỂ

Abstract

We examined the effects of natural curcuminoids natural turmeric
extract on mitochondrial function and on the development of human multiple myeloma cell
line (KMS-20). We found that Cu, CuT2 and positive control drugs (DOX, RES) effectively
reduced the survival rate of KMS-20 cell compared to those in DMSO-treated cells.
Similar to DOX and RES, cardiolipin contents, a lipid component of inner mitochondrial
membrane, were significantly decreased in Cu- and CuT2-cancer cells (38.09±14.52,
47.87±12.48, respectively, p<0.05); while in DMSO group, this value was 100.00±3.78.
Interestingly, levels mitochondrial membrane potential and reactive oxygen spices were
also markedly altered in DOX-, RES-, Cu-, and CuT2-treated KMS-20 cells. Overall, our
results documented for the first time the evidence the roles of natural curcuminoids in
suppressing the development of KMS-20 and in changing mitochondrial function.