NGHIÊN CỨU ĐỘC TÍNH CỦA VIÊN KHỚP VINTONG TRÊN THỰC NGHIỆ

Abstract

Objectives: 1) Study of the toxicity level of "Viên khớp VINTONG” remedy on experimental animals. 2) Study of the Semi-Chronic toxicity of "Viên khớp VINTONG" remedy on experimental animals. Methods: Evaluating the acute toxicity of “Viên khớp VINTONG" remedy in oral mice by Litchfield-Wilcoxon method. Evaluating the Semi-Chronic toxicity of “Viên khớp VINTONG” remedy on oral rat following the rules and guidelines of the Ministry of the Health. Results: Acute Toxicity: the LD50 of "Vien khop VINTONG" extract was not found in oral mice. The mice were given the highest dose of 42.0 g/kg/day. Semi-Chronic toxicity: On the rat used "Vien khop VINTONG” extract with dose of 1.40g/extract/day and dose of 7.0g/extract/day in 90 continuous days, it shows that: Rats are healthy and good weigh gain; not alter the hematological indexes; Not change the blood biochemical to evaluating the liver and kidney function; not damage histology of liver, spleen, kidney. Thus, “Vien khop VINTONG” is safe at dosage and used intervals.