ĐÁNH GIÁ ĐỘC TÍNH CẤP VÀ ẢNH HƯỞNG CỦA BÀI THUỐC MINH NÃO VINTONG ĐỐI VỚI THỂ TRẠNG CHUNG VÀ CÁC CHỈ SỐ HUYẾT HỌC TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objective: To evaluate the acute toxicity in mice and its affects on rat's health, weight and
hematology indexs of the "Minh nao vintong" remedy. Methods: Acute toxicity in Swiss mice was assessed according to Litchfield - Wilcoxon method [2] and WHO guidelines. The effects of the remedy on general health and hematological indicators were evaluated when given to rats
daily for 90 days. Results: Swiss mice were drank "Minh nao vintong" with 6 doses from 90 g/kg to 240 g/kg body weight, 0.2mL/10g/time x 3 times/day, but no mice died or had any usually within 7 days after taking the drug. On Wistar rats drinking " Minh nao vintong" during 90 days, the condition and body weight of the rats were normal, the hematological indicators (erythrocytes, hemoglobin, hematocrit, mean corpuscular volume, white blood cells, platelets) of
rats in the group taking the drug did not differ from the control group as well as before taking the drug. Conclusions: The acute toxicity not identify the LD50 on mice although they were taken the highest dose of 240g herbal medicines/kg body weight. After 90 days of treatment with the doses of 8.54g/kg per day and 25.62g/kg per day, “Minh nao vintong" did not caused any harm to rat's health, body weight and the hematology indexs.