ĐÁNH GIÁ ẢNH HƯỞNG CỦA VIÊN ANDIABET ĐẾN TÍNH KHÁNG INSULIN Ở CHUỘT NHẮT GÂY ĐÁI THÁO ĐƯỜNG TYPE 2

Abstract

Objective: The antagonism with insulin resistance of Andiabet in T2D mice model, directly evaluation by hyperinsulinemic-euglycemic clamp in conscious, unrestrained mice. Methods: the technique "Hyperinsulinemic - euglycemic clamp test" was used to assess insulin resistance. Results: The weight of mice in the HFD group increased respectively by 42.5 %; 64.4 % and 85.8 % after 4, 6 and 8 weeks (p <0.001). 72h after injection of STZ, blood glucose levels in HFD group increased strongly (207,4%) compared with before injection of STZ (p < 0,001). At doses of 1 g/kg and 2 g/kg, Andiabet reduced insulin resistance by direct evaluation throught the hyperinsulinemic-euglycemic clamp in conscious, unrestrained STZ mice. Conclusion: These findings suggested the effective mechanisms of Andiabet to be insulin resistance reduction, as a scientific basis to develop drugs treatment DM from a natural source of research.