IMMUNOENHANCEMENT EFFECTS OF THE HERBAL FORMULA ANTI-U200 ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE

Abstract

Anti-U200 is an herbal blend comprising Ganoderma lucidum, Hedyotis diffusa, and Scutellaria barbata is known to have immunomodulatory effects. Objectives: We examined the immuno-enhancing effect of this herbal blend on cyclophosphamide (CYP)-induced immunosuppression. Methods: Swiss mice were assigned to one of five groups: the intact control and four CYP treatment groups (one control, one reference (levamisole), and two with the application of Anti-U200 at different dosages; 1.92 or 5.76 capsules/kg). Mice received one of the experimental treatments after being injected with CYP to induce myelosuppression and immunosuppression. Results: Anti-U200 therapy improved lymphoid organ atrophy in histological assessments and ameliorated the CYP-induced decreases in spleen and thymus weights in immunosuppressed animals. It also led to beneficial changes in leucocyte counts and boosted TNF-α and IgM serum levels. Conclusions: We have proven that Anti-U200, a combination of three immunomodulatory herbs, is an efficient immunomodulatory agent that can strengthen the immune system.