TÁC DỤNG CHỐNG VIÊM CỦA VIÊN NANG THÔNG XOANG VƯƠNG HV TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objective: Evaluating the acute and chronic anti-inflammatory effects of Thong xoang vuong HV capsules in experimental animals. Methods: Acute anti-inflammatory effect was evaluated on peritonitis model in Swiss mice. Chronic anti-inflammatory effect was evaluated on the granuloma model in Wistar rats. Results: Thong xoang vuong HV at dose 960 mg/kg/24h and 1920 mg/kg/24h orally for 5 days showed acute antiinflammatory effect on the model of peritonitis in Swiss mice, reduced inflammatory fluid volume, decreased protein level and white blood cell count in inflammatory exudate (p < 0.05 compared to model group), equivalent to diclofenac 15 mg/kg/24h. Thong xoang vuong HV at dose 560mg/kg/day and dose of 1120mg/kg/day orally for 7 days showed chronic anti-inflammatory effect on the the granuloma model in Wistar rats, reducing the weight of wet granuloma (post-dissection) and weight of dry granuloma (after drying), with p <0.05 compared to the pathology group, equivalent to Prednisolon at dose of 15mg/kg/24h. Conclusion: Thong xoang vuong HV capsule has acute and chronic antiinflammatory in experimental animals.