ĐÁNH GIÁ TÁC DỤNG GIẢM NHU ĐỘNG RUỘT CỦA BÀI THUỐC “ĐẠI TRÀNG - HV” TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objective: To evaluate the effect of reducing peristalsis of the water extract of "Dai trang HV" remedy on experimental animals. Methods: Evaluate the effect of reducing peristalsis by measuring the amplitude and frequency of contraction of rabbit intestines isolated by Magnus method, and measuring the mobility of color indicator in the in the intestines of the Swiss mice according to Dobrescu's method. Results: The water extract of "Dai trang HV" remedy when tested on isolated rabbit intestines reduced the frequency of contractions at concentrations of 2% (p<0.05) and 3% (p<0.01), decreased amplitude
of contractility at concentrations of 1%, 2% (p<0.05) and 3% (p<0.01) compared to before using the drug. When giving Swiss mice at dose of 22g/kg/day and 44g/kg/day reduces peristalsis by reducing the mobility of color indicator (activated carbon) in the intestine (p<0.05 compared to the control group). This effect of " Dai trang HV" is equivalent to Duspatalin 80 mg/kg/day. Conclusions: The water extract of "Dai trang HV" remedy had a effect on reducing peristalsis in experimental animals.