NGHIÊN CỨU ĐẶC ĐIỂM TEST THẦN KINH TỰ CHỦ TRONG BỆNH TEO ĐA HỆ THỐNG TẠI BỆNH VIỆN ĐA KHOA TÂM ANH, HÀ NỘI

Abstract

Objectives. To describe the characteristics of autonomic tests on patients with multiple system atrophy at Tam Anh General Hospital and to describe the relationship between autonomic test results and disease severity. Methods Cross-sectional study.Result. Among 24 patients (12 male, 12 female, the mean age of 62.54 ± 7.81 years) with Multiple System Atrophy, based on the Consensus Statement on the Diagnosis of Multiple Systemic Atrophy 2008, autonomic tests including 6 tests were conducted. All patients had abnormalities in at least 2 tests. The average number of abnormal tests was 3.83 ±1.34. The average Ewing score was 2.63 ± 0.95. The highest abnormal rate is in the isometric exercise test - Handgrip test (95.83%), followed by the heart rate variability test to deep breathing (91.67%). The rates of abnormality found in Valsalva test, standing blood pressure test, sympathetic skin response test, standing heart rate variability test were 70.83%, 58.33%, 45.83%, 20.83%, respectively. The total Ewing score had a weak positive correlation with the UPDRS III scale (r=0.387, p=0.062 > 0.05) but had a strong positive correlation with total UMSARS and UMSARS II scales with correlation coefficients of 0.668; 0.549, respectively (p<0.05). Conclude. In multiple system atrophy, there are abnormalities in autonomic function tests with rates varying from 20.83% to 95.83%. There is a positive correlation between the severity of abnormal autonomic tests (Ewing score) with the severity of the disease (total UMSARS).