KHẢO SÁT TỈ LỆ VÀ MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN MỨC ĐỘ NẶNG CỦA BỆNH NHÂN KHÔ MẮT DO RỐI LOẠN CHỨC NĂNG TUYẾN BỜ MI

Abstract

Objective: To investigate the clinical characteristics and some factors associated with the severity of dry eye disease (DED) due to meibomian gland dysfunction (MGD). Methods: A cross-sectional descriptive study was conducted on 40 patients (80 eyes) diagnosed with MGD-related DED at Can Tho Eye–Dental–Maxillofacial Hospital. Symptom severity was assessed using the Ocular Surface Disease Index (OSDI). Results: In 80 eyes, dry eye disease due to meibomian gland dysfunction was predominantly severe by OSDI (86.2%). The most common symptoms were dryness, foreign body sensation, and tearing. Clinical findings showed marked tear film instability and ocular surface damage, with low TBUT, high CFS, and advanced MGD severity. OSDI was negatively correlated with TBUT and positively correlated with CFS, meibum quality, lid margin telangiectasia, and MGD severity. Multivariable analysis identified decreased TBUT, increased CFS, MQ ≥ 12, and lid margin telangiectasia ≥ grade 2 as independent factors associated with severe disease. Conclusion: The severity of MGD-related DED is closely associated with tear film instability, ocular surface damage, and lid margin inflammation.