KHẢO SÁT MỐI LIÊN QUAN GIỮA CHỈ SỐ NT-PROBNP VÀ PHÂN SUẤT TỐNG MÁU (EF) Ở BỆNH NHÂN SUY TIM MẠN TÍNH ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA TIỀN GIANG

Abstract

Objectives: To describe NT-proBNP levels and left ventricular ejection fraction (LVEF), determine their association, and evaluate the predictive value of NT-proBNP for reduced LVEF (LVEF < 40%) in patients with chronic heart failure. Methods: A cross-sectional analytical study was conducted on 71 patients with chronic heart failure hospitalized at the Department of Cardiology, Tien Giang General Hospital, from January to December 2024. Plasma NT-proBNP levels were measured using a chemiluminescent immunoassay, and LVEF was assessed by echocardiography using the biplane Simpson method. Statistical analyses included group comparisons, Pearson correlation, receiver operating characteristic (ROC) curve analysis, and multivariable regression. Results: The mean NT-proBNP level was 10766 ± 11204 pg/mL in the LVEF < 40% group, significantly higher than in the LVEF 40–49% group (4143 ± 3218 pg/mL) and the LVEF ≥ 50% group (2717 ± 1905 pg/mL) (p = 0.012). NT-proBNP showed a moderate negative correlation with LVEF (r = −0.33; p = 0.005). NT-proBNP predicted LVEF < 40% with an AUC of 0.815, an optimal cutoff value of 2194.5 pg/mL, sensitivity of 73.7%, and specificity of 84.8%. Conclusion: NT-proBNP levels increase as LVEF decreases and show a statistically significant inverse correlation with LVEF. NT-proBNP is a useful biomarker for screening reduced ejection fractions in patients with chronic heart failure, particularly in settings where echocardiography is limited.