ĐÁNH GIÁ KHẢ NĂNG LÀM LÀNH VẾT THƯƠNG BỎNG CỦA CAO CHIẾT NẤM LINH CHI Ganoderma lucidum TRÊN MÔ HÌNH GÂY BỎNG THỰC NGHIỆM Ở CHUỘT NHẮT TRẮNG

Abstract

Objective: This study aimed to evaluate the burn wound healing potential of Ganoderma lucidum extract using an experimental skin burn model in white mice. Methods: Burn wounds were induced using a cylindrical metal tool with a 1 cm diameter. Forty-five white mice with Grade II burns were randomly assigned to three experimental groups: a model control, a treatment group receiving G. lucidum extract, and a positive control group treated with Levigatus turmeric cream. Wound healing progress was monitored and assessed; histological analysis of skin tissue cross-sections was performed on days 1, 3, 7, 10, and 14. Additionally, the phytochemical composition and antibacterial activity of the G. lucidum extract were qualitatively analyzed. Results: The G. lucidum extract revealed the presence of various bioactive secondary metabolites, including terpenoids, coumarin, tannin, polysaccharides, flavonoids, and quinones. The extract exhibited potent antibacterial and bactericidal activity against both Gram-negative and Gram-positive bacteria at concentrations < 31.25 mg/mL. Notably, the extract significantly promoted burn wound healing, resulting in complete recovery without scarring after 14 days of treatment. These results were statistically significant compared to the other two experimental groups (p < 0.05). Conclusion: Ganoderma lucidum extract possesses immense biological potential for application in the development of pharmaceutical preparations for wound treatment.