NỒNG ĐỘ MỘT SỐ HORMON TRÊN BỆNH NHÂN NỮ GIỚI MẮC THALASSEMIA TRONG ĐỘ TUỔI TIỀN SINH SẢN CÓ QUÁ TẢI SẮT TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Background: Female Thalassemia patients in the pre-reproductive age are severely affected by iron overload, leading to endocrine dysfunction and impaired reproductive development. Objective: To determine the levels of selected female reproductive hormones and evaluate the relationship between hormone levels and iron overload. Methods: A cross-sectional, retrospective study was conducted on 45 female patients aged 12 – 18 years, treated at the Hematology Department, Thai Nguyen Central Hospital. Hormones measured included LH, FSH, Estradiol, Progesterone, and Prolactin. Iron overload was assessed using biochemical indices (serum ferritin, serum iron). Results: The mean hormone levels were as follows: • LH: 4,4 ± 2,6 mIU/mL • FSH: 6,8 ± 2,9 mIU/mL • Estradiol: 60,5 ± 31,5 pg/mL • Progesterone: 4,6 ± 13,4 ng/mL • Prolactin: 185,9 ± 136,0 mIU/mL Female reproductive hormones decreased proportionally with the degree of iron overload. Iron overload showed negative correlations with LH, FSH, Estradiol, and Prolactin, and a positive correlation with Progesterone. The prevalence of delayed puberty and hypogonadism increased with the severity of iron overload. Conclusion: Iron overload has a significant impact on female reproductive hormones in Thalassemia patients. Early monitoring and intervention are essential to prevent future reproductive dysfunction.