Efficacy of Botulinum toxin A in treatment of primary hemifacial spasm

Abstract

Objective: Evaluating the effects of toxin botulinum A in treatment of primary hemifacial spasm. Methods: A total of 48 patients with primary hemifacial spasm were treated by injections of botulinum toxin A (Dysport) in Tam Anh Hospital from 6/2020 to 5/ 2021. Methods: Prospective, descriptive study. Results: Forty-eight patients (8 male, 40 female) were included in the study, the ages were from 36 to 79 years with an average age of 57 ± 10,43 years, having mean Jankovic disability rating scale score of 3.25±0.55SD. MRI revealed vascular compression in all patients. The dose Dysport was 80-145UI; 91,7% reported improvement after 2 weeks - 1 month from the injected. Benefits begin in 2-7 days after the treatment and last for an average of 5,50 ± 0,97 months (3-8 months). Side effects such as ectropion (45,83%), ptosis (4,2%), and hematoma (12,5%) are transient and reversible after 1-3 weeks. No severe complication was noted. Conclusions: This finding show that local botulinum toxin treatment provides effective and safe relief of hemifacial spasm.