KẾT QUẢ SÀNG LỌC HIV, HBV, HCV Ở NGƯỜI HIẾN MÁU TẠI VIỆN HUYẾT HỌC – TRUYỀN MÁU TRUNG ƯƠNG (2017-2022)

Abstract

ABSTRACT

RESULTS OF SCREENING FOR HIV, HBV, HCV IN BLOOD DONORS AT NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION (2017-2022)

  MSc. Dr. Ha Huu Nguyen*, MSc. Nguyen Thi Thanh Dung*, M.D. Dr. Tran Ngoc Que*,

M.D. Dr. Bach Quoc Khanh*, AP. M.D. Dr. Bui Thi Mai An**

* National Institute of Hematology and Blood Transfusion

                                    ** Phenikaa University

Background: Screening for HIV, HCV, HBV and syphilis for blood donors is a mandatory test according to the provisions of Circular 26/TT-BYT to detect, counsel and take care of blood donors’ health. It is also an effective measure to prevent transmission of HIV, HBV, HCV and syphilis to blood recipients.

Objective: To investigate HIV, HBV, HCV and syphilis screening results for voluntary blood donors who donate whole blood at National Institute of Hematology and Blood Transfusion (NIHBT) for the period 2017 - 2022

Method: Cross-sectional description, prospective study of 1,087,520 voluntary blood donors who donate whole blood with 1,995,614 blood donations. Investigate HIV, HBV, HCV and syphilis screening test results by serological testing and NAT testing in voluntary blood donors who donate whole blood.

Result:

Serological testing:

• The rate of HBsAg, HIV antigen-antibody, HCV antibody and syphilis antibody being positive in 1,995,614 blood samples of voluntary blood donors who donate whole blood was respectively: 0.51%; 0.05% and 0.089% and 0.076%.


• The rate of HBsAg, HIV antigen-antibody, HCV antibody and syphilis antibody being positive by gender: Male and female: HBsAg (+): 0.99% and 0.86%; HCV antibody (+): 0.23% and 0.06%; HIV antigen-antibody (+): 0.11% and 0.07%; syphilis antibody (+): 0.18% and 0.1%.


• The rate in blood donors by age: HBsAg (+): 0.77%, 0.93% and 1.3%; HCV antibody (+): 0.04% and 0.21%, 0.34%; HIV antigen-antibody (+): 0.1%, 0.08% and 0.1%; syphilis antibody (+): 0.09% and 0.15%, 0.23%.


• The rate in first time blood donors and repeat blood donors: HBsAg (+): 1.55% and 0.15%; HCV antibody (+): 0.29% and 0.02%; HIV antigen-antibody (+): 0.1% and 0.03%; syphilis antibody (+): 0.18% and 0.04%.

NAT testing: The rate of HCV-RNA, HIV-RNA and HBV-DNA being positive in 1,087,520 voluntary blood donors who donate whole blood with 1,981,171 blood donations was: HCV – RNA: 0.0023% (1: 44,026), HIV – RNA : 0.0005% (1: 198.117) and HBV-DNA: 0.083% (1: 1,192. Repeat blood donors had higher rates of HBV-DNA, HCV-RNA than first time donors;

Conclusion:

Serological testing result: The rate of HBsAg, HCV antibody, HIV antigen-antibody, syphilis antibody being positive was respectively 0.51%; 0.089%; 0.05% and 0.076%. The rate of HBsAg, HCV antibody, antigen-antibody HIV, syphilis antibody in men was higher than in women, and that in first time donors was higher than repeat donors, the rate of HBsAg, HCV antibody and syphilis antibody being positive increased with age of blood donors

NAT testing result: The positive rate of HBV - DNA was 0.083% (1: 1.192), HCV - RNA was 0.0023% (1: 44,026), HIV - RNA was 0.0005 % (1: 198.117), repeat blood donors had a higher rate of HBV – DNA, HCV – RNA than that of first-time blood donors;