ẢNH HƯỞNG MỘT SỐ YẾU TỐ NGUY CƠ ĐẾN THỰC TRẠNG RỐI LOẠN ĐÔNG MÁU VÀ NGUY CƠ XUẤT HUYẾT DO QUÁ LIỀU CHỐNG ĐÔNG KHÁNG VITAMIN K

Abstract

Objectives: Research effects of factors to coagulation and the risk of bleeding on 79 patients in over-anticoagulation with anti-vitamin k at Hai Phong - Vinh Bao International General Hospital, Vietnam. Methods: Description and Salvation study. In our tertiary care anticoagulation hospital patients with a INR testing index of more than over anticoagulation with vitamin k and chek INR with every 4 weeks. Results: The average research have age is 65.65 ± 12.17 years [33:85], all most of the elderly group (73.4%). The men group (31.65%) are lower than women group (68.35%) but there is no statistical difference (p > 0.05). Patients with hemorrahage signs account for 22.8%. The INR testing index has an average value is 5.88 ± 3.0 [3.02 - 23.95]. The group of INR> 5 level (51.9%) and the group of INR ≤5 level (48.1%) have the same ratio.  The group of INR> 5 level is a higher risk of bleeding than the group of INR ≤5 level (p <0.001). Patients using coenzyme Q10 and green vegetable nutrition (Turnip Green) are quite common (accounting for 31.6% and 35.4%), its affect to coagulation with vitamin K and the cause of increased risk of bleeding with the rate of the difference is 5.28 (CI: 1.72-16.17, with P <0.01) and 2.99 (CI: 1.01-8.80, with P < 0.05) of statistical significance. Conclusion: All most patients in over-anticoagulation are elderly group. The men group are lower than women group but there is no statistical difference. It have no difference between the group of INR> 5 level and the group of INR ≤5 level. Patients with hemorrahage signs account for 22.8%, The group of INR> 5 level is a higher risk of bleeding than the group of INR ≤5 level, it’s statistical significance (p <0.001). Patients using coenzyme Q10 and green vegetable nutrition are quite common, its affect to coagulation and the cause of increased risk of bleeding, its affect to coagulation with vitamin K and the cause of increased risk of bleeding with the rate of the difference with statistical significance.